Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008839)
Formula	Hydrolysis
	Reactant	Ivosidenib	Product	Ivosidenib M39 metabolite
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Hydrolysis - Hydrolysis

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR008841	Ivosidenib	Ivosidenib M30 metabolite	Oxidation - N-dealkylation	Ivosidenib	[1]
MR008842	Ivosidenib	Ivosidenib metabolite M44	Oxidation - N-dearylation	Ivosidenib	[1]
MR008843	Ivosidenib	Ivosidenib metabolite M5	Unclear - Unclear	Ivosidenib	[2]
MR008844	Ivosidenib	Ivosidenib metabolite M6	Unclear - Unclear	Ivosidenib	[2]

Other MR(s) Related to The Product of This MR

Other MR(s) That Metabolize The Produtc of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR008840	Ivosidenib M39 metabolite	Ivosidenib M37 metabolite	Oxidation - Hydroxylation	Ivosidenib	[3]

References
1	Pharmacokinetics, absorption, metabolism, and excretion of [(14)C]ivosidenib (AG-120) in healthy male subjects
2	Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant Isocitrate Dehydrogenase 1 for Treatment of Isocitrate Dehydrogenase 1-Mutant Malignancies
3	DrugBank(Pharmacology-Metabolism):Ivosidenib

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