Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009254)
Formula
CYP3A4 ...
SVG example
Unclear
Reactant Beclomethasone dipropionate Product Delta6-BDP
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009253 Beclomethasone dipropionate 6beta-OH-BDP Unclear - Unclear Beclomethasone dipropionate [1]
MR009246 Beclomethasone dipropionate Beclomethasone-17-monopropionate (17-BMP) Hydrolysis - Hydrolysis Beclomethasone dipropionate [2]
MR009251 Beclomethasone dipropionate Beclomethasone-21-monopropionate (21-BMP) Hydrolysis - Hydrolysis Beclomethasone dipropionate [3]
References
1 Metabolism of beclomethasone dipropionate by cytochrome P450 3A enzymes. J Pharmacol Exp Ther. 2013 May;345(2):308-16.
2 DrugBank(Pharmacology-Metabolism):Beclomethasone dipropionate
3 Comparative kinetics of metabolism of beclomethasone propionate esters in human lung homogenates and plasma

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