Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009309)
Formula Reactant NB-506 Product ED-501
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009312 NB-506 ED-551 Unclear - Unclear NB-506 [1]
MR009313 NB-506 ED-594 Unclear - Unclear NB-506 [1]
MR009311 NB-506 RBM-1 Conjugation - 11-O-glucosidation NB-506 [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009310 ED-501 RBM-2 Conjugation - 11-O-glucosidation NB-506 [3]
References
1 In vitro metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo+ ++[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione (NB-506), in mice, rats, dogs, and humans
2 Simultaneous determination of a new anticancer agent (NB-506) and its active metabolite in human plasma and urine by high-performance liquid chromatography with ultraviolet detection
3 In vivo metabolism of a new anticancer agent, 6-N-formylamino-12, 13-dihydro-1,11-dihydroxy-13-(beta-D-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506) in rats and dogs: pharmacokinetics, isolation, identification, and quantification of metabolites

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