Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009337)
Formula
SVG example
Unclear
Reactant Napitane mesilate Metabolite M1 Product Napitane mesilate Metabolite M4
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009336 Napitane mesilate Napitane mesilate Metabolite M1 Oxidation - Oxidation Napitane mesilate [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009343 Napitane mesilate Metabolite M1 Napitane mesilate Metabolite M10 Multi-steps Reaction - Glucuronidation; sulfation Napitane mesilate [1]
MR009341 Napitane mesilate Metabolite M1 Napitane mesilate Metabolite M2 Multi-steps Reaction - Glucuronidation; sulfation Napitane mesilate [1]
MR009342 Napitane mesilate Metabolite M1 Napitane mesilate Metabolite M3 Conjugation - Glucuronidation Napitane mesilate [1]
MR009339 Napitane mesilate Metabolite M1 Napitane mesilate Metabolite M6 Unclear - Unclear Napitane mesilate [1]
MR009345 Napitane mesilate Metabolite M1 Napitane mesilate Metabolite M8 Conjugation - Sulfation Napitane mesilate [1]
MR009344 Napitane mesilate Metabolite M1 Napitane mesilate Metabolite M9 Conjugation - Sulfation Napitane mesilate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009338 Napitane mesilate Metabolite M4 Napitane mesilate Metabolite M5 Conjugation - Glucuronidation Napitane mesilate [1]
References
1 Implication of P450-metabolite complex formation in the nonlinear pharmacokinetics and metabolic fate of (+/-)-(1'R*,3R*)-3-phenyl-1-[(1',2',3',4'-tetrahydro-5',6'-methylene-dioxy-1'-naphthalenyl) methyl] pyrrolidine methanesulfonate (ABT-200) in dogs

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