Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009575)
Formula
SVG example
Methylhydroxylation
Reactant Ropivacaine hydrochloride Product 2-Hydroxymethylropivacaine
Reactant Info Product Info
Metabolic Type Oxidation - Methylhydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009568 Ropivacaine hydrochloride 3-hydroxyropivacaine Oxidation - 3-hydroxylation Ropivacaine hydrochloride [1]
MR009570 Ropivacaine hydrochloride 4-Hydroxyropivacaine Oxidation - 4-hydroxylation Ropivacaine hydrochloride [2]
MR009572 Ropivacaine hydrochloride PPX Oxidation - N-dealkylation Ropivacaine hydrochloride [3], [4]
References
1 Lack of metabolic racemisation of ropivacaine, determined by liquid chromatography using a chiral AGP column
2 Metabolism and excretion of ropivacaine in humans
3 Regional transport and metabolism of ropivacaine and its CYP3A4 metabolite PPX in human intestine. J Pharm Pharmacol. 2003 Jul;55(7):963-72.
4 Effect of propofol on ropivacaine metabolism in human liver microsomes

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