Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009620)
Formula
SVG example
Glucuronidation
Reactant Siponimod M5 Product Siponimod M3
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009618 BAF-312 Siponimod M5 Oxidation - Hydroxylation BAF-312 [1]
MR002269 Siponimod Siponimod metabolite M5 Unclear Siponimod [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009619 Siponimod M5 Siponimod M4a Oxidation - Sulfonation BAF-312 [1]
MR002264 Siponimod metabolite M5 Siponimod metabolite M4a Unclear Siponimod [1]
References
1 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.

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