Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009639)
Formula	Glucuronidation
	Reactant	Tretinoin	Product	Retinoyl beta-glucuronide
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009631	Tretinoin	13-cis RA	Other reaction - Isomerization	Tretinoin	[1], [2]
MR009636	Tretinoin	18-OH-RA	Oxidation - Hydroxylation	Tretinoin	[3], [2], [1]
MR009637	Tretinoin	3,4-Didehydroretinoic acid	Oxidation - Oxidation	Tretinoin	[4]
MR009626	Tretinoin	4-Hydroxyretinoic acid	Oxidation - 4-hydroxylation	Tretinoin	[3], [1]
MR009629	Tretinoin	5,6-epoxy-RA	Oxidation - Ring epoxidation	Tretinoin	[2], [2], [3]
MR009634	Tretinoin	9-cis RA	Other reaction - Isomerization	Tretinoin	[1], [2]
MR009638	Tretinoin	Retinotaurine	Oxidation - Oxidation	Tretinoin	[4]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006384	NSC-122758	Retinoyl b-glucuronide	Conjugation - Glucuronidation	NSC-122758	[3]

References
1	Human cytochrome P450s involved in the metabolism of 9-cis- and 13-cis-retinoic acids
2	Retinoic acid metabolism and mechanism of action: a review
3	Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites. Mol Pharmacol. 2000 Dec;58(6):1341-8.
4	Clinical pharmacokinetics of tretinoin

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