Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009851)
Formula
UGT1A9 ...
SVG example
Glucuronidation
Reactant Ambrisentan Product Ambrisentan glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009849 Ambrisentan 4-hydroxymethyl?ambrisentan Oxidation - Oxidation Ambrisentan [1], [2]
References
1 Effect of ketoconazole on the pharmacokinetic profile of ambrisentan. J Clin Pharmacol. 2009 Jun;49(6):719-24.
2 Potential for pharmacokinetic interactions between ambrisentan and cyclosporine. Clin Pharmacol Ther. 2010 Oct;88(4):513-20.

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