Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009854)
Formula Reactant Amitriptyline hydrochloride Product Nortriptyline
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009860 Amitriptyline hydrochloride (E)-10-hydroxyamitriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
MR009858 Amitriptyline hydrochloride (Z)-10-hydroxyamitriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009856 Nortriptyline (E)-10-hydroxynortriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
MR009857 Nortriptyline (Z)-10-hydroxynortriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
MR009855 Nortriptyline Demethylnortriptyline Unclear - Unclear Amitriptyline hydrochloride [1], [2]
References
1 CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies
2 Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype

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