Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009876)
Formula	Lactonization
	Reactant	4-hydroxyatorvastatin acid	Product	4-hydroxyatorvastatin lactone
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Lactonization

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009875	Atorvastatin calcium	4-hydroxyatorvastatin acid	Unclear - Unclear	Atorvastatin calcium	[1]

Other MR(s) Related to The Product of This MR

Other MR(s) That Produce The Product of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR009879	Atorvastatin lactone	4-hydroxyatorvastatin lactone	Unclear - Unclear	Atorvastatin calcium	[2]

References
1	Influence of Drug-Drug Interactions on the Pharmacokinetics of Atorvastatin and Its Major Active Metabolite ortho-OH-Atorvastatin in Aging People Living with HIV
2	Rifampin markedly decreases and gemfibrozil increases the plasma concentrations of atorvastatin and its metabolites

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