Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010063)
Formula Reactant ABT-418 Product ABT-418 Metabolite M2
Reactant Info Product Info
Metabolic Enzyme Flavin-containing monooxygenase (FMO) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010062 ABT-418 ABT-418 Metabolite M1 Oxidation - N'-oxidation ABT-418 [1], [2]
References
1 The in vitro hepatic metabolism of ABT-418, a cholinergic channel activator, in rats, dogs, cynomolgus monkeys, and humans
2 In vitro hepatic metabolism of ABT-418 in chimpanzee (Pan troglodytes). A unique pattern of microsomal flavin-containing monooxygenase-dependent stereoselective N'-oxidation

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