| General Information of This Metabolic Reaction (MR) (ID:
MR010398) |
| Formula |
|
| Reactant |
PF-04937319 |
Product |
PF-04937319 Metabolite M1 |
|
Reactant Info
|
Product Info
|
|
Metabolic Enzyme
|
Cytochrome P450 3A4 (CYP3A4)
|
DME Info
|
|
Cytochrome P450 2C9 (CYP2C9)
|
DME Info
|
|
Mephenytoin 4-hydroxylase (CYP2C19)
|
DME Info
|
|
Metabolic Type
|
Oxidation
-
N-demethylation
|
|
|
|
|
|
|
|
| Other MR(s) Related to The Product of This MR |
|
Other MR(s) That Metabolize The Produtc of This MR
|
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|
| References |
| 1 |
Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling
|
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