Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010558)
Formula
SVG example
Unclear
Reactant Divalproex sodium Product 4-OH-VPA
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A (CYP3A) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010559 Divalproex sodium (3E)-2-propylpent-3-enoic acid Unclear - Unclear Divalproex sodium [1]
MR010560 Divalproex sodium (3Z)-2-propylpent-3-enoic acid Unclear - Unclear Divalproex sodium [1]
MR010552 Divalproex sodium 2-ene-VPA Unclear - Unclear Divalproex sodium [1]
MR010557 Divalproex sodium 3-OH-VPA Unclear - Unclear Divalproex sodium [1]
MR010554 Divalproex sodium 4-ene-VPA Unclear - Unclear Divalproex sodium [1]
MR010556 Divalproex sodium 5-OH-VPA Unclear - Unclear Divalproex sodium [1]
MR010561 Divalproex sodium VPA beta-O-glucuronide Unclear - Unclear Divalproex sodium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002492 Valproic acid 4-hydroxyvalproic acid Oxidation - 4-Hydroxylation Valproic acid [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002486 4-hydroxyvalproic acid 2-N-Propyl-4-oxopentanoic acid Oxidation - Dehydrogenation Valproic acid [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 PharmGKB: the Pharmacogenomics Knowledge Base Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20.

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