Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010642)
Formula
SVG example
Unclear
Reactant N-Desmethyl sumatriptan Product Indo-3-yl-acetaldehyde derivative
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase type A (MAO-A) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010640 Sumatriptan N-Desmethyl sumatriptan Unclear - Unclear Sumatriptan [1]
MR010641 N-Desmethyl sumatriptan N-Desmethyl sumatriptan Unclear - Unclear Sumatriptan [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010641 N-Desmethyl sumatriptan N-Desmethyl sumatriptan Unclear - Unclear Sumatriptan [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013303 Cinnarizine Cinnarizine metabolite M1 Unclear Cinnarizine [2]
MR010627 Cyclizine Norcyclizine Oxidation - N-Desmethylation Cyclizine [3]
MR010646 Sumatriptan Indo-3-yl-acetaldehyde derivative Unclear - Unclear Sumatriptan [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010628 Norcyclizine Hydroxynorcyclizine Oxidation - Heterocyclic Ring Hydroxylation Cyclizine [3]
MR010643 Indo-3-yl-acetaldehyde derivative Indo-3-yl-acetic acid derivative Unclear - Unclear Sumatriptan [1]
References
1 Metabolism of sumatriptan revisited
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Biotransformation of cyclizine in greyhounds. 1: Identification and analysis of cyclizine and some basic metabolites in canine urine by gas chromatography-mass spectrometry

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