Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010969)
Formula Reactant Pexidartinib Product Pexidartinib Metabolite M5
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002871 Pexidartinib N-glucuronide?metabolite Conjugation - Glucuronidation Pexidartinib [1]
MR010968 Pexidartinib Pexidartinib Metabolite M1 Multi-steps Reaction - Oxidative dealkylation glucuronidation Pexidartinib [2]
MR010970 Pexidartinib Pexidartinib Metabolite M2 Multi-steps Reaction - Epoxidation; epoxide htdrolysis Pexidartinib [2]
MR010971 Pexidartinib Pexidartinib Metabolite M3 Oxidation - Oxidation Pexidartinib [2]
MR010966 Pexidartinib Pexidartinib Metabolite M4 Oxidation - Oxidation Pexidartinib [2]
References
1 FDA label of Pexidartinib. The 2020 official website of the U.S. Food and Drug Administration.
2 Pharmacokinetics of the Multi-kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality

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