Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011040)
Formula
SVG example
Unclear
Reactant Taxol Product 6alpha-hydroxypaclitaxel
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010220 Taxol 6alpha,3'p-dihydroxypaxlitaxel Unclear - Unclear Taxol [1]
MR010218 Taxol 6alpha-hydroxypaclitaxel?(6alpha-OHP) Unclear - Unclear Taxol [2]
MR011041 Taxol p-3'-hydroxypaclitaxel Unclear - Unclear Taxol [2]
MR010219 Taxol p-3-hydroxypaclitaxel Unclear - Unclear Taxol [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001909 Paclitaxel 6alpha-hydroxypaclitaxel Oxidation - Hydroxylation Paclitaxel [3]
References
1 Metabolism of paclitaxel in mice
2 The Quantification of Paclitaxel and Its Two Major Metabolites in Biological Samples by HPLC-MS/MS and Its Application in a Pharmacokinetic and Tumor Distribution Study in Xenograft Nude Mouse
3 Noise in an ac biased junction: Nonstationary Aharonov-Bohm effect Phys Rev Lett. 1994 Jan 24;72(4):538-541. doi: 10.1103/PhysRevLett.72.538.

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