Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011145)
Formula
SVG example
Oxidation
Reactant BMS-201038 Product Lomitapide Metabolite M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011144 BMS-201038 Lomitapide Metabolite M1 Oxidation - N-dealkylation BMS-201038 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006894 Lomitapide mesylate Lomitapide metabolite M3 Unclear Lomitapide mesylate [2]
References
1 LABEL: JUXTAPID- lomitapide mesylate capsule
2 Evaluation of the effects of the weak CYP3A inhibitors atorvastatin and ethinyl estradiol/norgestimate on lomitapide pharmacokinetics in healthy subjects. J Clin Pharmacol. 2016 Jan;56(1):47-55.

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