Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011195)
Formula
SVG example
Unclear
Reactant N,N-Didesmethyldiphenhydramine Product Diphenylmethoxyacetic acid
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000872 N-desmethyldiphenhydramine N,N-didesmethyldiphenhydramine Oxidation - N-Demethylation Diphenhydramine [1], [2], [3]
MR011194 N-Desmethyldiphenhydramine N,N-Didesmethyldiphenhydramine Unclear - Unclear Dimenhydrinate [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000874 N,N-didesmethyldiphenhydramine N-acetyl-N-desmethyldiphenhydramine Conjugation - Acetylation Diphenhydramine [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000875 Diphenylmethoxyacetic acid . Conjugation - Conjugation Diphenhydramine [4]
References
1 Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007 Jan;35(1):72-8.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3 Bioconcentration, metabolism and effects of diphenhydramine on behavioral and biochemical markers in crucian carp (Carassius auratus) Sci Total Environ. 2016 Feb 15;544:400-9. doi: 10.1016/j.scitotenv.2015.11.132.
4 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.