Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011383)
Formula
SVG example
Unclear
Reactant Chlorpromazine Product Demonomethylchlorpromazine
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011381 Chlorpromazine Chlorpromazine-N-oxide Unclear - Unclear Chlorpromazine [1]
MR011382 Chlorpromazine Dedimethylchlorpromazine Unclear - Unclear Chlorpromazine [1]
MR011380 Chlorpromazine Hydroxychlorpromazine Oxidation - 7-hydroxylation Chlorpromazine [1]
MR011384 Chlorpromazine Opromazine Oxidation - S-oxidation Chlorpromazine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000642 Chlorpromazine hydrochloride Demonomethylchlorpromazine Unclear Chlorpromazine hydrochloride [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000641 Demonomethylchlorpromazine Dedimethylchlorpromazine Unclear Chlorpromazine hydrochloride [3]
References
1 DrugBank(Pharmacology-Metabolism):Chlorpromazine
2 Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704.
3 Classics in Chemical Neuroscience: Chlorpromazine ACS Chem Neurosci. 2019 Jan 16;10(1):79-88. doi: 10.1021/acschemneuro.8b00258.
4 Determination of chlorpromazine and its metabolites in animal-derived foods using QuEChERS-based extraction, EMR-Lipid cleanup, and UHPLC-Q-Orbitrap MS analysis. Food Chem. 2023 Mar 1;403:134298. doi: 10.1016/j.foodchem.2022.134298.

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