Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR011626)
Formula
SVG example
N-dealkylation
Reactant MLN4924 Product MLN4924 Metabolite M7
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR011622 MLN4924 MLN4924 Metabolite M1 Oxidation - Hydroxylation MLN4924 [1]
MR011627 MLN4924 MLN4924 Metabolite M16 Conjugation - Glucuronidation MLN4924 [1]
MR011628 MLN4924 MLN4924 Metabolite M22,10b Multi-steps Reaction - Glucuronidation; Hydroxylation MLN4924 [1]
MR011624 MLN4924 MLN4924 Metabolite M3 Oxidation - Hydroxylation MLN4924 [1]
References
1 Metabolism and Disposition of [(14)C]Pevonedistat, a First-in-Class NEDD8-Activating Enzyme Inhibitor, after Intravenous Infusion to Patients with Advanced Solid Tumors

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