General Information of This Metabolic Reaction (MR) (ID: MR012019)
Formula
SVG example
O-desmethylation
Reactant Fruquintinib Product M379-2
Reactant Info Product Info
Metabolic Type Oxidation - O-desmethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012030 Fruquintinib M205 Unclear - Unclear fruquintinib [1]
MR012015 Fruquintinib M379-1 Unclear - Unclear fruquintinib [2], [3]
MR012028 Fruquintinib M380 Unclear - Unclear fruquintinib [4]
MR012034 Fruquintinib M409-1 Unclear - Unclear fruquintinib [5], [3]
MR012023 Fruquintinib M409-2 Oxidation - Mono-oxidation fruquintinib [6], [3]
MR012010 Fruquintinib M409-3 Oxidation - Mono-oxidation fruquintinib [7]
MR012033 Fruquintinib M409-4 Oxidation - Mono-oxidation fruquintinib [8], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012021 M379-2 M365-1 Unclear - Unclear fruquintinib [9]
MR012020 M379-2 M365-2/3 Unclear - Unclear fruquintinib [10]
MR012022 M379-2 M555-2 Unclear - Unclear fruquintinib [11]
References
1 Locus coeruleus neuronal activity correlates with behavioral response to acute and chronic doses of methylphenidate (Ritalin) in adolescent rats
2 Incarceration of the medial collateral ligament in the intercondylar notch following proximal avulsion
3 Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics
4 Spontaneous thrombosis of a giant cerebral varix in a pediatric patient
5 Esophageal bezoar due to karaya gum granules used as a laxative
6 A simple and rapid infrared-assisted self enzymolysis extraction method for total flavonoid aglycones extraction from Scutellariae Radix and mechanism exploration
7 A phase I study to investigate the metabolism, excretion, and pharmacokinetics of [(14)C]fruquintinib, a novel oral selective VEGFR inhibitor, in healthy Chinese male volunteers
8 Management of postoperative junctional ectopic tachycardia in pediatric patients: a survey of 30 centers in Germany, Austria, and Switzerland
9 Disposable electrochemical immunosensor for Brettanomyces bruxellensis based on nanogold-reduced graphene oxide hybrid nanomaterial
10 Exhaled breath online measurement for cervical cancer patients and healthy subjects by proton transfer reaction mass spectrometry
11 TLC surface integrity affects the detection of alkali adduct ions in TLC-MALDI analysis

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