Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012054)
Formula Reactant FG-4592 Product FG-4592 Metabolites M1-M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012063 FG-4592 FG-4592 Metabolites M4 Unclear - Unclear FG-4592 [1]
MR012066 FG-4592 FG-4592 Metabolites M5 Oxidation - Dealkylation FG-4592 [1]
MR012061 FG-4592 FG-4592 Metabolites M8 Conjugation - Glucuronidation FG-4592 [1]
MR012067 FG-4592 Photo isomer Unclear - Unclear FG-4592 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012055 FG-4592 Metabolites M1-M3 FG-4592 Metabolites M11 Oxidation - Sulfonation FG-4592 [1]
MR012058 FG-4592 Metabolites M1-M3 FG-4592 Metabolites M7 Hydrolysis - Hydrolysis FG-4592 [1]
MR012060 FG-4592 Metabolites M1-M3 FG-4592 Metabolites M9 Conjugation - Glucuronidation FG-4592 [1]
References
1 Identification of Hypoxia-inducible factor (HIF) stabilizer roxadustat and its possible metabolites in thoroughbred horses for doping control

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