Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012220)
Formula Reactant PD-153035 Product PD-153035 M3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A (CYP3A) DME Info
Cytochrome P450 2D (CYP2D) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012218 PD-153035 PD-153035 M1 Oxidation - N-oxidation PD-153035 [1]
MR012219 PD-153035 PD-153035 M2 Oxidation - 7-O-desmethylation PD-153035 [1]
References
1 Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats

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