Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012245)
Formula Reactant X-396 Product X-396 M737
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012246 X-396 X-396 M346 Hydrolysis - Hydrolysis X-396 [1]
MR012240 X-396 X-396 M371 Oxidation - O-dealkylation X-396 [1]
MR012238 X-396 X-396 M465 Hydrolysis - Hydrolysis X-396 [1]
MR012244 X-396 X-396 M521 Oxidation - N,N-depropylation X-396 [1]
MR012243 X-396 X-396 M577a/b Oxidation - Mono-oxidation X-396 [1]
MR012232 X-396 X-396 M577c/M577 Oxidation - Mono-oxidation X-396 [1]
MR012242 X-396 X-396 M577d Unclear - Unclear X-396 [1]
References
1 Mass balance, metabolic disposition, and pharmacokinetics of [(14)C]ensartinib, a novel potent anaplastic lymphoma kinase (ALK) inhibitor, in healthy subjects following oral administration

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