Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012496)
Formula
SVG example
O-demethylation
Reactant YM-758 Product YM-394112
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012493 YM-758 Precursor Oxidation - Hydroxylation YM-758 [1]
MR012495 YM-758 YM-394111 Oxidation - O-demethylation YM-758 [1]
References
1 Evaluation of the inhibitory and induction potential of YM758, a novel If channel inhibitor, for human P450-mediated metabolism

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