Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012820)
Formula
SVG example
Demethylation
Reactant Colchicine Product 3-O-desmethylchochicine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012819 Colchicine 2-O-demethylcolchicine Oxidation - Demethylation Colchicine [1]
MR012818 Colchicine Colchicine metabolite M1 Unclear Colchicine [2]
MR012814 Colchicine Colchicine metabolite M6 Unclear Colchicine [2]
MR012811 Colchicine Colchicine metabolite M7 Unclear Colchicine [2]
MR012817 Colchicine Colchicine metabolite M8 Unclear Colchicine [2]
References
1 Colchicine-antimicrobial drug interactions: what pharmacists need to know in treating gout
2 Identification of novel metabolites of colchicine in rat bile facilitated by enhanced online radiometric detection

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