Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR012955)
Formula Reactant PCI-45773 (M35) Product Ibrutinib Metabolite M17
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012954 Ibrutinib PCI-45773 (M35) Oxidation - Hydrolyzationn Ibrutinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR012959 PCI-45752 (M34) Ibrutinib Metabolite M17 Oxidation - Hydrolyzationn Ibrutinib [2]
References
1 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
2 DrugBank(Pharmacology-Metabolism):Ibrutinib

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