General Information of This Metabolic Reaction (MR) (ID:
MR013043) |
Formula |
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Reactant |
Darexaban maleate |
Product |
Darexaban glucuronide |
Reactant Info
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Product Info
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Metabolic Enzyme
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UDP-glucuronosyltransferase 1A10 (UGT1A10)
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DME Info
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UDP-glucuronosyltransferase 1A7 (UGT1A7)
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DME Info
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UDP-glucuronosyltransferase 1A8 (UGT1A8)
|
DME Info
|
UDP-glucuronosyltransferase 1A9 (UGT1A9)
|
DME Info
|
Metabolic Type
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Unclear
-
Unclear
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Other MR(s) Related to The Reactant of This MR |
Other MR(s) That Metabolize The Reactant of This MR
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Other MR(s) Related to The Product of This MR |
Other MR(s) That Metabolize The Produtc of This MR
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References |
1 |
Absorption, metabolism and excretion of darexaban (YM150), a new direct factor Xa inhibitor in humans
|
2 |
Identification of enzymes responsible for the N-oxidation of darexaban glucuronide, the pharmacologically active metabolite of darexaban, and the glucuronidation of darexaban N-oxides in human liver microsomes
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