Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013056)
Formula
SVG example
27-O-demethylation
Reactant Rifabutin Product 27-O-demethylrifabutin
Reactant Info Product Info
Metabolic Type Oxidation - 27-O-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013060 Rifabutin 20-Hydroxyrifabutin Oxidation - Hydroxylation Rifabutin [1]
MR013057 Rifabutin 25-O-deacetylrifabutin Oxidation - Deacetylation Rifabutin [2]
MR013058 Rifabutin 31-Hydroxyrifabutin Oxidation - Hydroxylation Rifabutin [1]
MR013059 Rifabutin 32-Hydroxyrifabutin Oxidation - Hydroxylation Rifabutin [1]
MR013061 Rifabutin Unclear Unclear - Unclear Rifabutin [3]
References
1 Isolation and identification of major urinary metabolites of rifabutin in rats and humans
2 Tolerance and pharmacokinetic interactions of rifabutin and clarithromycin in human immunodeficiency virus-infected volunteers
3 The effect of multiple doses of ritonavir on the pharmacokinetics of rifabutin. Clin Pharmacol Ther. 1998 Apr;63(4):414-21.

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