Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013066)
Formula
SVG example
Reduction
Reactant Rofecoxib Product Rofecoxib-erythro-3,4-dihydrohydroxy acid
Reactant Info Product Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013071 Rofecoxib 4'-Hydroxyrofecoxib-O-bate-D-glucuronide Conjugation - Glucuronidation Rofecoxib [1]
MR013062 Rofecoxib 5-OH-rofecoxib Other reaction - Hydoxylation Rofecoxib [2]
MR013064 Rofecoxib Dihydro-5-OH-rofecoxib Unclear - Unclear Rofecoxib [2]
MR013068 Rofecoxib Rofecoxib-threo-3,4-dihydrohydroxy acid Unclear - Unclear Rofecoxib [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013067 Rofecoxib-erythro-3,4-dihydrohydroxy acid Cis -Dihydrorofecoxib Unclear - Unclear Rofecoxib [2]
References
1 The disposition and metabolism of rofecoxib, a potent and selective cyclooxygenase-2 inhibitor, in human subjects
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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