Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013082)
Formula
CYP3A4 ...
SVG example
N-oxidation
Reactant Zotepine Product Zotepine N-oxide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Dimethylaniline oxidase 3 (FMO3) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013083 Zotepine 2-OH-zotepine Oxidation - Aromatic hydroxylation Zotepine [1]
MR013084 Zotepine 3-OH-zotepine Oxidation - Aromatic hydroxylation Zotepine [1]
MR013081 Zotepine Norzotepine Oxidation - N-demethylation Zotepine [1], [2]
MR013085 Zotepine Zotepine S-oxide Oxidation - S-oxidation Zotepine [1]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake

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