Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013098)
Formula
SVG example
Deiodination
Reactant Amiodarone hydrochloride Product B2-O-Et-N-dipropyl
Reactant Info Product Info
Metabolic Type Reduction - Deiodination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013097 Amiodarone hydrochloride Amiodarone hydrochloride Metabolite M1 Oxidation - O-deakylation Amiodarone hydrochloride [1]
MR013095 Amiodarone hydrochloride Amiodarone hydrochloride Metabolite M2 Oxidation - HYDROXYLATION Amiodarone hydrochloride [1]
MR013093 Amiodarone hydrochloride Mono-N-desethylamiodarone Oxidation - N-dealkylation Amiodarone hydrochloride [2], [3], [4]
References
1 Pharmacology and pharmacokinetics of amiodarone
2 Determination of the cardiac drug amiodarone and its N-desethyl metabolite in sludge samples
3 Amiodarone and concurrent antiretroviral therapy: a case report and review of the literature
4 The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59.

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