Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013250)
Formula
CYP3A4 ...
SVG example
Hydrolyzationn
Reactant Voriconazole Product 4-Hydroxyvoriconazole
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013245 Voriconazole Voriconazole N-Oxide Metabolite Oxidation - Oxidationn Voriconazole [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013251 4-Hydroxyvoriconazole 4-Hydroxyvoriconazole 4-O-glucuronide metabolite Conjugation - O-glucuronidation Voriconazole [1], [2]
References
1 The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human
2 Roles of CYP3A4 and CYP2C19 in methyl hydroxylated and N-oxidized metabolite formation from voriconazole, a new anti-fungal agent, in human liver microsomes. Biochem Pharmacol. 2007 Jun 15;73(12):2020-6.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.