Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013296)
Formula
SVG example
N-dehydroxylation
Reactant Zileuton Product Dehydroxyzyleuton
Reactant Info Product Info
Metabolic Type Reduction - N-dehydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013299 Zileuton Hydroxyzileuton Oxidation - Hydrolyzationn Zileuton [1], [2]
MR013301 Zileuton Zileuton O-glucuronide metabolite Conjugation - N-hydroxy glucuronidation Zileuton [1], [2]
MR013300 Zileuton Zileuton sulfoxide Oxidation - Sulfoxidation Zileuton [1], [2]
MR005683 Zileuton Zolmitriptan N-oxide Oxidation - N-oxidation Zolmitriptan [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013297 Dehydroxyzyleuton Dehydroxyzileuton sulfoxide metabolite Oxidation - Sulfoxidation Zileuton [1], [2]
MR013298 Dehydroxyzyleuton OH-dehydroxyzileuton Oxidation - Hydrolyzationn Zileuton [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
3 Indolealkylamines: biotransformations and potential drug-drug interactions
4 Determination of the human cytochrome P450 isoforms involved in the metabolism of zolmitriptan. Xenobiotica. 1999 Aug;29(8):847-57.

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