Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013340)
Formula Reactant KRM-1648 Product 30-hydroxy-benzoxazinorifamycin
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013338 KRM-1648 25-deacetyl-benzoxazinorifamycin Oxidation - 25-deacetylation KRM-1648 [1], [2]
MR013342 KRM-1648 32-hydroxy-benzoxazinorifamycin. Oxidation - 32-hydroxylation KRM-1648 [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013341 30-hydroxy-benzoxazinorifamycin 25-deacetyl- 30-hydroxy-benzoxazinorifamycin. Oxidation - Deacetylation KRM-1648 [2]
References
1 Pharmacokinetics of KRM-1648, a new benzoxazinorifamycin, in rats and dogs
2 Identification and antimicrobial activity of urinary metabolites of a rifamycin derivative in dog
3 DrugBank : KRM-1648

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