Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013350)
Formula Reactant CBT-1 Product O-demethylated tetrandrine
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013353 CBT-1 CBT-1 Metabolite M2 Oxidation - Demethylation CBT-1 [1]
MR013354 CBT-1 CBT-1 Metabolite M3 Oxidation - Demethylation CBT-1 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013351 O-demethylated tetrandrine Quinone methide Unclear CBT-1 [2]
References
1 Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 mice
2 CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine. Arch Toxicol. 2016 Jul;90(7):1737-48.

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