Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013387)
Formula
SVG example
Reactant Methylphenidate Product Ethylphenidate
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase 1 (CES1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013369 Methylphenidate 6-Oxo-MPH Unclear Methylphenidate [1]
MR013394 Methylphenidate Alpha-phenyl-2-piperidine acetic acid (ritalinic acid) Hydrolysis - Esterase hydrolyzation Methylphenidate [2], [3]
MR013392 Methylphenidate Carbamide MPH Unclear Methylphenidate [1]
MR013383 Methylphenidate p-Hydroxy-MPH Unclear Methylphenidate [1]
MR013382 Methylphenidate Ritalic acid Unclear Methylphenidate [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013389 Ethylphenidate 4-Hydroxy-EPH Unclear Methylphenidate [1]
MR013388 Ethylphenidate 5-Hydroxy-EPH Unclear Methylphenidate [1]
MR013390 Ethylphenidate Ethyl 3-amino-6-oxo-2-phenylhexanoate Unclear Methylphenidate [1]
References
1 Metabolomics of Methylphenidate and Ethylphenidate: Implications in Pharmacological and Toxicological Effects
2 Metabolism of methylphenidate in dog and rat
3 Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1. J Pharmacol Exp Ther. 2004 Aug;310(2):469-76.

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