Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013397)
Formula
SVG example
Reactant Metoclopramide hydrochloride Product Monodeethylmetoclopramide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013398 Metoclopramide hydrochloride Metoclopramide Conjugated metabolite Conjugation - Sulfation Metoclopramide hydrochloride [1], [2]
MR013399 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M1 Multi-steps Reaction - Oxidationn; followed by glucuronidation Metoclopramide hydrochloride [3]
MR013406 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M10 Oxidation - Nitration Metoclopramide hydrochloride [3]
MR013400 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M2 Conjugation - Sulfonylation Metoclopramide hydrochloride [3]
MR013401 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M3 Oxidation - N-dealkylation Metoclopramide hydrochloride [3]
MR013395 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M4 Oxidation - Oxidationn Metoclopramide hydrochloride [3]
MR013402 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M5 Unclear Metoclopramide hydrochloride [3]
MR013403 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M6 Unclear Metoclopramide hydrochloride [3]
MR013404 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M7 Conjugation - Glucuronidation Metoclopramide hydrochloride [3]
MR013405 Metoclopramide hydrochloride Metoclopramide hydrochloride Metabolite M9 Other reaction - N-carbamoylation Metoclopramide hydrochloride [3]
References
1 Clinical pharmacokinetics of metoclopramide
2 Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. Xenobiotica. 2014 Apr;44(4):309-319.
3 Identification of novel metoclopramide metabolites in humans: in vitro and in vivo studies

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