Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013429)
Formula Reactant BIBR1087/M1 Product Dabigatran M630
Reactant Info Product Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013428 Dabigatran etexilate BIBR1087/M1 Hydrolysis - Hydrolysis Dabigatran etexilate [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013430 Dabigatran M630 Dabigatran M602 Unclear Dabigatran etexilate [4]
References
1 The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans
2 Conventional liquid chromatography/triple quadrupole mass spectrometry based metabolite identification and semi-quantitative estimation approach in the investigation of in vitro dabigatran etexilate metabolism. Anal Bioanal Chem. 2013 Feb;405(5):1695-704.
3 Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis
4 DrugBank(Pharmacology-Metabolism): Dabigatran etexilate

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