Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013454)
Formula
SVG example
N-dealkylation
Reactant 1-(3-chlorophenyl) piperazine Product Etoperidone Metabolite N9
Reactant Info Product Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013453 Etoperidone 1-(3-chlorophenyl) piperazine Unclear Etoperidone [1], [2]
MR004891 Nefazodone M-Chlorophenylpiperazine Unclear Nefazodone [3]
MR002444 Trazodone hydrochloride M-chlorophenylpiperazine Oxidation - N-Dealkylation Trazodone hydrochloride [4]
MR004886 Hydroxynefazodone M-Chlorophenylpiperazine Unclear Nefazodone [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004887 M-Chlorophenylpiperazine p-hydroxy-mCPP Unclear Nefazodone [3]
References
1 Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man
2 In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62.
3 Clinical pharmacokinetics of nefazodone. Clin Pharmacokinet. 1997 Oct;33(4):260-75.
4 Pharmacokinetics of trazodone and its major metabolite m-chlorophenylpiperazine in plasma and brain of rats Int J Neuropsychopharmacol. 1999 Mar;2(1):17-23. doi: 10.1017/S1461145799001303.

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