Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013460)
Formula Reactant Etoperidone Product Etoperidone Metabolite M12
Reactant Info Product Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013453 Etoperidone 1-(3-chlorophenyl) piperazine Unclear Etoperidone [1], [2]
MR013469 Etoperidone 1-(3-chlorophenyl) piperazine (M22) Oxidation - N-dealkylation Etoperidone [1]
MR013465 Etoperidone Etoperidone Metabolite M19 Oxidation - Oxidationn Etoperidone [1]
MR013442 Etoperidone Etoperidone Metabolite M2 Oxidation - Oxidationn Etoperidone [1], [2]
MR013466 Etoperidone Etoperidone Metabolite M20 Oxidation - Oxidationn Etoperidone [1]
MR013467 Etoperidone Etoperidone Metabolite M21 Oxidation - Oxidationn Etoperidone [1]
MR013468 Etoperidone Etoperidone Metabolite M4 Oxidation - Aromatic hydroxylation Etoperidone [1]
MR013451 Etoperidone Etoperidone Metabolite M5 Oxidation - Hydrolyzationn Etoperidone [1], [2]
MR013458 Etoperidone Etoperidone Metabolite M6 Oxidation - N-dealkylation Etoperidone [1]
MR013455 Etoperidone Etoperidone Metabolite N6 Unclear Etoperidone [1]
MR013464 Etoperidone N-oxide etoperidone Oxidation - Oxidationn Etoperidone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013461 Etoperidone Metabolite M12 Etoperidone Metabolite M13 Conjugation - Methylationn Etoperidone [1]
MR013462 Etoperidone Metabolite M12 Etoperidone Metabolite M14 Oxidation - Hydrolyzationn Etoperidone [1]
MR013463 Etoperidone Metabolite M12 Etoperidone Metabolite M18 Conjugation - Conjugation Etoperidone [1]
References
1 Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man
2 In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica. 2002 Nov;32(11):949-62.

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