Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR013900)
Formula Reactant Losartan Product LN2G
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013896 Losartan E 3179 Unclear - Unclear Losartan [1]
MR013899 Losartan LN1G Unclear - Unclear Losartan [2]
MR013898 Losartan LOG Unclear - Unclear Losartan [2]
References
1 Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814.
2 The human UDP-glucuronosyltransferase UGT1A3 is highly selective towards N2 in the tetrazole ring of losartan, candesartan, and zolarsartan. Biochem Pharmacol. 2008 Sep 15;76(6):763-72.

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