Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR014160)
Formula Reactant Ciclosporin Product AM1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014166 Ciclosporin AM4N Oxidation - Oxidation Ciclosporin [1]
MR014164 Ciclosporin AM9 Oxidation - Hydroxylation Ciclosporin [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR014185 AM1 AM11d Unclear - Unclear Ciclosporin [1]
MR014163 AM1 AM19 Oxidation - Hydroxylation Ciclosporin [2]
MR014181 AM1 AM1AL Unclear - Unclear Ciclosporin [1]
MR014184 AM1 AM1c Unclear - Unclear Ciclosporin [1]
References
1 Cyclosporin metabolism in transplant patients
2 High-performance liquid chromatographic method for the simultaneous determination of cyclosporine A and its four major metabolites in whole blood Talanta. 2005 Feb 15;65(3):638-43. doi: 10.1016/j.talanta.2004.07.048.

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