Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00007)
Xenobiotics Name
Azathioprine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
2265
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldo-keto reductase 1D1 (AKR1D1) DME Info Homo sapiens [1]
Aminomuconic semialdehyde dehydrogenase (ALDH12) DME Info Homo sapiens [1]
Asparagine synthetase (ASNS) DME Info Homo sapiens [2]
DOPA decarboxylase (DDC) DME Info Homo sapiens [1]
Dipeptidyl peptidase IV (DPP4) DME Info Homo sapiens [3]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [1]
Gamma-Glu-X carboxypeptidase (GGH) DME Info Homo sapiens [1]
HMG-CoA reductase (HMGCR) DME Info Homo sapiens [1]
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DME Info Homo sapiens [2]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [1]
Methylsterol monooxygenase 1 (MSMO1) DME Info Homo sapiens [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
Xylosyl phosphatase (PXYLP1) DME Info Homo sapiens [1]
Thymidylate synthase (TYMS) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Small intestine reductase (AKR1B10) DME Info Homo sapiens [4], [1]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [1]
Aldo-keto reductase 1C2 (AKR1C2) DME Info Homo sapiens [4], [1]
Aldehyde oxidase (AOX1) DME Info Homo sapiens [2]
Cytochrome P450 2S1 (CYP2S1) DME Info Homo sapiens [1]
Glutathione reductase (GSR) DME Info Homo sapiens [4]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [1]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [1]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [1]
References
1 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
2 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
3 Severe villus atrophy and chronic malabsorption induced by azathioprine. Gastroenterology. 2003 Jun;124(7):1950-7.
4 Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.

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