Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00015)
Xenobiotics Name
Cimetidine
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=2756"></iframe>
3D MOL 2D MOL
PubChem CID
2756
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [1]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 2D6 (CYP2D6) DME Info Homo sapiens [3]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [1]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Cytochrome P450 2D6 (CYP2D6) DME Info Ki = 77 microM [3]
Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 15 microM [4]
References
1 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
2 Size-dependent effects of nanoparticles on the activity of cytochrome P450 isoenzymes. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):326-32.
3 Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr Drug Metab. 2005 Oct;6(5):413-54.
4 Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. J Med Chem. 2003 Apr 24;46(9):1716-25.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.