Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00028)
Xenobiotics Name
Disulfiram
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
<iframe style="width: 300px; height: 300px;" frameborder="0" src="https://embed.molview.org/v1/?mode=balls&cid=3117"></iframe>
3D MOL 2D MOL
PubChem CID
3117
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Aldehyde dehydrogenase 1 (ALDH1) DME Info Homo sapiens [1]
Retinal dehydrogenase 2 (ALDH1A2) DME Info Homo sapiens [2]
Aldehyde dehydrogenase 2 (ALDH2) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [3]
Corticosteroid 11-beta-dehydrogenase 2 (HSD11B2) DME Info Homo sapiens [4]
DME(s) Induced by This Xenobiotics
Aldo-keto reductase 1B1 (AKR1B1) DME Info Homo sapiens [5]
Small intestine reductase (AKR1B10) DME Info Homo sapiens [5]
Aldo-keto reductase 1C1 (AKR1C1) DME Info Homo sapiens [5]
Aldo-keto reductase 1C3 (AKR1C3) DME Info Homo sapiens [5]
Catalase (CAT) DME Info Homo sapiens [5]
Glutathione reductase (GSR) DME Info Homo sapiens [5]
Metallothionein-2A (MT2A) DME Info Homo sapiens [6]
Quinone reductase 1 (NQO1) DME Info Homo sapiens [5]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [5]
Superoxide dismutase 1 (SOD1) DME Info Homo sapiens [5]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [5]
UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info Homo sapiens [5]
References
1 A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cells. Cancer Lett. 2011 Jan 1;300(1):87-95.
2 The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance. Chem Biol Interact. 2012 Jan 5;195(1):52-60.
3 Direct and metabolism-dependent cytochrome P450 inhibition assays for evaluating drug-drug interactions. J Appl Toxicol. 2013 Feb;33(2):100-8.
4 Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
5 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
6 High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.