Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00036)
Xenobiotics Name
Fluconazole
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3365
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [3], [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Mephenytoin 4-hydroxylase (CYP2C19) DME Info IC50 = 8.2 microM [1]
Cytochrome P450 2C9 (CYP2C9) DME Info IC50 = 13 microM [2]
Cytochrome P450 3A4 (CYP3A4) DME Info IC50 = 8 microM [3], [4]
References
1 Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
2 Design and optimization of highly-selective, broad spectrum fungal CYP51 inhibitors. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3243-3248.
3 CYP3A4 substrate selection and substitution in the prediction of potential drug-drug interactions. J Pharmacol Exp Ther. 2005 Jul;314(1):180-90.
4 Identification of cytochrome P450 and arylamine N-acetyltransferase isoforms involved in sulfadiazine metabolism. Drug Metab Dispos. 2005 Jul;33(7):969-76.

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