Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00037)
Xenobiotics Name
Fluorouracil
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3385
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
D-Lactate dehydrogenase (ldhA) DME Info Pseudomonas aeruginosa [1]
Arylamine N-acetyltransferase (NAT) DME Info Pseudomonas aeruginosa [1]
Hydroxybenzoate 3-monooxygenase (pobA) DME Info Pseudomonas aeruginosa [1]
Prostaglandin G/H synthase 2 (COX-2) DME Info Homo sapiens [2]
Thioredoxin reductase TR1 (TXNRD1) DME Info Homo sapiens [3]
Thymidine phosphorylase (TYMP) DME Info Homo sapiens [4]
Thymidylate synthase (TYMS) DME Info Homo sapiens [5], [6]
DME(s) Induced by This Xenobiotics
Carboxylesterase 2 (CES2) DME Info Homo sapiens [7]
Dihydrofolate reductase (DHFR) DME Info Homo sapiens [8], [9]
Dihydrothymine dehydrogenase (DPYD) DME Info Homo sapiens [10], [11]
Thymidylate kinase (DTYMK) DME Info Homo sapiens [8]
Cellular glutathione peroxidase (GPX1) DME Info Homo sapiens [12]
Glutathione S-transferase pi (GSTP1) DME Info Homo sapiens [13]
Glutathione S-transferase theta-1 (GSTT1) DME Info Homo sapiens [14], [15]
Adenosine 5'-monophosphoramidase (HINT1) DME Info Homo sapiens [14], [15]
Nitric oxide synthase inducible (NOS2) DME Info Homo sapiens [16]
Ecto-5'-nucleotidase (NT5E) DME Info Homo sapiens [17]
Prostaglandin reductase 1 (PTGR1) DME Info Homo sapiens [14]
Putrescine acetyltransferase (SSAT1) DME Info Homo sapiens [9]
Uridine phosphorylase 1 (UPP1) DME Info Homo sapiens [18]
References
1 Effect of quorum quenching lactonase in clinical isolates of Pseudomonas aeruginosa and comparison with quorum sensing inhibitors. Front Microbiol. 2017 Feb 14;8:227.
2 Curcumin enhances the effects of 5-fluorouracil and oxaliplatin in mediating growth inhibition of colon cancer cells by modulating EGFR and IGF-1R. Int J Cancer. 2008 Jan 15;122(2):267-73.
3 Expression profiling of nucleotide metabolism-related genes in human breast cancer cells after treatment with 5-fluorouracil. Cancer Invest. 2009 Jun;27(5):561-7.
4 Influence of chemotherapeutic agents and cytokines on the expression of 5-fluorouracil-associated enzymes in human colon cancer cell lines. J Gastroenterol. 2006 Feb;41(2):140-50.
5 Pharmacokinetics of S-1, an oral formulation of ftorafur, oxonic acid and 5-chloro-2,4-dihydroxypyridine (molar ratio 1:0.4:1) in patients with solid tumors. Cancer Chemother Pharmacol. 2003 Jul;52(1):1-12.
6 Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels. Br J Cancer. 2007 Mar 12;96(5):769-75.
7 Schedule-dependent cytotoxicity of 5-fluorouracil and irinotecan in a colon cancer cell line. J Gastroenterol. 2006 Dec;41(12):1149-57.
8 Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols. Mol Cancer. 2004 Apr 26;3:11.
9 Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and -resistant ovarian cancer cells. Amino Acids. 2012 Feb;42(2-3):641-53.
10 Synergistic effects of docetaxel and S-1 by modulating the expression of metabolic enzymes of 5-fluorouracil in human gastric cancer cell lines. Int J Cancer. 2006 Aug 15;119(4):783-91.
11 Expression of dihydropyrimidine dehydrogenase, thymidylate synthase, p53 and p21 in metastatic liver tumor from colorectal cancer after 5-fluorouracil-based chemotherapy. Anticancer Res. 2005 Mar-Apr;25(2B):1237-42.
12 Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
13 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
14 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
15 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
16 Mechanism of apoptotic effects induced by 5-fluorouracil on human liver carcinoma Bel7402 cell line. Chin Med J (Engl). 2002 Jul;115(7):968-71.
17 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
18 Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. Cancer Lett. 2004 Oct 8;214(1):19-33.

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