Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00052)
Xenobiotics Name
Lansoprazole
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
3883
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Mephenytoin 4-hydroxylase (CYP2C19) DME Info Homo sapiens [1]
DME(s) Induced by This Xenobiotics
Cytochrome P450 1A1 (CYP1A1) DME Info Homo sapiens [2], [3]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [2], [4]
Cytochrome P450 1B1 (CYP1B1) DME Info Homo sapiens [5]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [4]
Xenobiotics-DME Activity Data
Xenobiotics-DME Activity Data Mephenytoin 4-hydroxylase (CYP2C19) DME Info IC50 = 0.3367 microM [1]
References
1 The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: implications for coadministration with clopidogrel. Drug Metab Dispos. 2011 Nov;39(11):2020-33.
2 Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture. J Pharmacol Exp Ther. 1994 Apr;269(1):384-92.
3 Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line. Xenobiotica. 1997 Jan;27(1):1-9.
4 An evaluation of the cytochrome P450 induction potential of pantoprazole in primary human hepatocytes. Chem Biol Interact. 1998 Jul 3;114(1-2):1-13.
5 Time-dependent transcriptional induction of CYP1A1, CYP1A2 and CYP1B1 mRNAs by H+/K+ -ATPase inhibitors and other xenobiotics. Xenobiotica. 2003 Feb;33(2):107-18.

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