Detail Information of Xenobiotics

General Information of Xenobiotics (ID: XEO00056)
Xenobiotics Name
Malathion
Xenobiotics Type
Pharmaceutical Agent(s)
Classification
Approved/Marketed Drug
Structure
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3D MOL 2D MOL
PubChem CID
4004
DME(s) Modulated by This Xenobiotics
DME(s) Inhibited by This Xenobiotics
Acetylcholinesterase (ACHE) DME Info Homo sapiens [1]
Butyrylcholine esterase (BCHE) DME Info Homo sapiens [1]
Cytochrome P450 2C9 (CYP2C9) DME Info Homo sapiens [2]
Cytochrome P450 2E1 (CYP2E1) DME Info Homo sapiens [2]
Thymidylate synthase (TYMS) DME Info Homo sapiens [3]
DME(s) Induced by This Xenobiotics
Catalase (CAT) DME Info Homo sapiens [4]
Cytochrome P450 1A2 (CYP1A2) DME Info Homo sapiens [5]
Cytochrome P450 2B6 (CYP2B6) DME Info Homo sapiens [6]
Cytochrome P450 3A4 (CYP3A4) DME Info Homo sapiens [7]
References
1 In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450. Toxicol In Vitro. 2011 Jun;25(4):890-6.
2 Preferential inhibition of paraoxonase activity of human paraoxonase 1 by negatively charged lipids. J Lipid Res. 2004 Dec;45(12):2211-20.
3 Assessment of the inhibition potential of Licochalcone A against human UDP-glucuronosyltransferases. Food Chem Toxicol. 2016 Apr;90:112-22.
4 Fe3 O4 nanoparticle redox system modulation via cell-cycle progression and gene expression in human mesenchymal stem cells. Environ Toxicol. 2016 Aug;31(8):901-12.
5 Lycopene: an antioxidant and radioprotector against gamma-radiation-induced cellular damages in cultured human lymphocytes. Toxicology. 2009 Jul 28;262(1):43-9.
6 Nickel alterations of TLR2-dependent chemokine profiles in lung fibroblasts are mediated by COX-2. Am J Respir Cell Mol Biol. 2008 May;38(5):591-9.
7 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.

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